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KMID : 0352719940180010044
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Journal of Ginseng Research
1994 Volume.18 No. 1 p.44 ~ p.48
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Panaxadiol and Panaxatriol from Panax ginseng C. A. Meyer Inhibit the Synthesis of Thrombroxane A2 in Adrenaline-Stimulated Human Platelet Aggregations
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Abstract
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In adrenaline-stimulated human platelets, panaxadiol(PD) and panaxatriol (PT) from Panax ginseng C. A. Meyer did not inhibit the Ca2+ -influx, but inhibited the formation of thromboxane A2 and the platelet aggregations. It seems that PD and PT
block a
pathyway interconverting arachidonic acids (20:4) to thromboxane A2(TXA2), because the amount Ca* which phospholipase C or phospholipase A2 requires to liberate 20:4 from membrane phospholipids was increased by PD and PT. These results mean that
PD
and
PT have an antiplatelet effect by inhibiting the formation of TXA2.
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